| Autor: |
Feitosa RS; Medical School, Health Sciences Center, Federal University of Piauí, Teresina, Brazil., Martins BP; Medical School, Health Sciences Center, Federal University of Piauí, Teresina, Brazil., Almeida LM; Medical School, Health Sciences Center, Federal University of Piauí, Teresina, Brazil., de Oliveira MB; Statistics Department, Nature Sciences Center, Federal University of Piauí, Teresina, Brazil., de Araújo RMS; Biochemistry and Pharmacology Department, Health Sciences Center, Federal University of Piauí, Teresina, Brazil., de Oliveira KA; Biochemistry and Pharmacology Department, Health Sciences Center, Federal University of Piauí, Teresina, Brazil. |
| Abstrakt: |
Hyperuricemia (HU) has been associated with cardiovascular risk and metabolic syndrome (MS) worldwide. However, inconsistencies about this relation are still reported, and it is not clear whether hyperuricemia is an independent risk factor for MS. The aim of this study was to determine hyperuricemia associations with systemic hypertension and MS in women from northeast Brazil. The study included 301 women. Hyperuricemia was considered for serum uric acid (SUA) ≥6 mg/dL. Insulin resistance (IR) was measured by TyG index (TyG ≥ 4.55). Fisher test and Multivariate logistic regression analyses estimated the association between hyperuricemia (or SUA level) and systemic hypertension and MS. Hyperuricemia association with systemic hypertension was independent of age, body-mass index (BMI), smoking and alcoholism (OR: OR: 4.6050; p = .000256), and MS components (OR: 4.1296; IC95% 1.8330_9.3033; p = .000621). Hyperuricemia increased risk of systemic hypertension by 4,6 -fold. SUA level was associated with MS, independently of other classic component factors of the syndrome (OR:1.34, p = .0129). Hyperuricemia and high SUA levels were associated with MS and systemic hypertension. Effect of hyperuricemia in systemic hypertension is independent of age, BMI, lifestyle, and MS factors. SUA levels are independently associated with MS. |
