Sida tuberculata: In vitro cytotoxicity and in vivo anti-inflammatory effect.

Autor: Silva da Rosa H; Biochemistry and Toxicology of Natural and Synthetic Products Laboratory, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil; Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil. Electronic address: hemerdarosa@gmail.com., Santos MC; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Costa MT; Biochemistry and Toxicology of Natural and Synthetic Products Laboratory, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil; Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Salgueiro A; Biochemistry and Toxicology of Natural and Synthetic Products Laboratory, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil; Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Duarte da Silva M; Postgraduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Rio Grande do Sul, Brazil., Nogueira-Librelotto DR; Postgraduate Program in Pharmaceutical Sciences, Federal University of Santa Maria, Rio Grande do Sul, Brazil., Jesse C; Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Machado MM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Souza de Oliveira LF; Postgraduate Program in Pharmaceutical Sciences, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Folmer V; Biochemistry and Toxicology of Natural and Synthetic Products Laboratory, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil; Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil., Mendez ASL; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2022 Apr 06; Vol. 287, pp. 114956. Date of Electronic Publication: 2021 Dec 26.
DOI: 10.1016/j.jep.2021.114956
Abstrakt: Ethnopharmacological Relevance: Sida tuberculata R. E. Fries (Malvaceae) is a pioneer species considered a weed in farm fields in Southern Brazil. Widely distributed in South Brazil, S. tuberculata is popularly used to treat inflammatory conditions.
Aims of the Study: The current study aimed to assess the in vitro cytotoxic and in vivo anti-inflammatory properties of S. tuberculata.
Materials and Methods: Initially, extracts obtained from leaves (STLE) and roots (STRE) were submitted to cytotoxicity tests using human leukocytes (non-malignant cell line) and HepG2 and MCF-7 (tumor cell lines). In sequence, anti-inflammatory properties were investigated against carrageenan-induced peritonitis model.
Results: In vitro analyses displayed a significant decrease in human leukocytes viability without genotoxic damage. IC 50 results from tumor cells presented significant decrease in cell viability, slightly more pronounced for STRE. In addition, STLE significantly inhibited the inflammatory and oxidative parameters (TBARS, NPSH, SOD, MPO activity, cell influx, and cytokines release).
Conclusion: Our findings indicate S. tuberculata extracts have cytotoxic potential more pronounced on tumor cell lines, as well as leaves extract shows a significant reduction in acute inflammation process, as already reported for Sida genus and specifically for this species.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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