Neurobiological Bases of Alcohol Consumption After Social Stress.

Autor:	Miczek KA; Department of Psychology, Tufts University, Medford, MA, USA. klaus.miczek@tufts.edu.; Department of Neuroscience, Tufts University, Boston, MA, USA. klaus.miczek@tufts.edu., DiLeo A; Department of Neuroscience, Tufts University, Boston, MA, USA., Newman EL; Department of Psychiatry, Harvard Medical School, Belmont, MA, USA., Akdilek N; Department of Psychology, Tufts University, Medford, MA, USA., Covington HE 3rd; Department of Psychology, Tufts University, Medford, MA, USA.
Jazyk:	angličtina
Zdroj:	Current topics in behavioral neurosciences [Curr Top Behav Neurosci] 2022; Vol. 54, pp. 245-281.
DOI:	10.1007/7854_2021_273
Abstrakt:	The urge to seek and consume excessive alcohol is intensified by prior experiences with social stress, and this cascade can be modeled under systematically controlled laboratory conditions in rodents and non-human primates. Adaptive coping with intermittent episodes of social defeat stress often transitions to maladaptive responses to traumatic continuous stress, and alcohol consumption may become part of coping responses. At the circuit level, the neural pathways subserving stress coping intersect with those for alcohol consumption. Increasingly discrete regions and connections within the prefrontal cortex, the ventral and dorsal striatum, thalamic and hypothalamic nuclei, tegmental areas as well as brain stem structures begin to be identified as critical for reacting to and coping with social stress while seeking and consuming alcohol. Several candidate molecules that modulate signals within these neural connections have been targeted in order to reduce excessive drinking and relapse. In spite of some early clinical failures, neuropeptides such as CRF, opioids, or oxytocin continue to be examined for their role in attenuating stress-escalated drinking. Recent work has focused on neural sites of action for peptides and steroids, most likely in neuroinflammatory processes as a result of interactive effects of episodic social stress and excessive alcohol seeking and drinking. (© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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