Associations of deformation-based brain morphometry with cognitive level and decline within older Blacks without dementia.

Autor: Fleischman DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago IL, USA; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago IL, USA. Electronic address: debra_fleischman@rush.edu., Arfanakis K; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago IL, USA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA., Leurgans SE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Preventive Medicine, Rush University Medical Center, Chicago IL, USA., Zhang S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA., Poole VN; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Orthopedic Surgery, Rush University Medical Center, Chicago IL, USA., Han SD; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Departments of Family Medicine and Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA; School of Gerontology, University of Southern California, Los Angeles, CA, USA., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA., Lamar M; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago IL, USA., Kim N; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago IL, USA; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago IL, USA.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2022 Mar; Vol. 111, pp. 35-43. Date of Electronic Publication: 2021 Nov 20.
DOI: 10.1016/j.neurobiolaging.2021.11.003
Abstrakt: Blacks are at higher risk of developing cognitive impairment with age than non-Hispanic Whites, yet most brain morphometry and cognition research is performed with White samples or with mixed samples that control for race or compare across racial groups. A deeper understanding of the within-group variability in associations between brain structure and cognitive decline in Blacks is critically important for designing appropriate outcomes for clinical trials, predicting adverse outcomes, and developing interventions to preserve cognitive function, but no studies have examined these associations longitudinally within Blacks. We performed deformation-based morphometry in 376 older Black participants without dementia and examined associations of deformation-based morphometry with cognitive level and decline for global cognition and five cognitive domains. After correcting for widespread age-associated effects, there remained regions with less tissue and more cerebrospinal fluid associated with level and rate of decline in global cognition, memory, and perceptual speed. Further study is needed to examine the moderators of these associations, identify adverse outcomes predicted by brain morphometry, and deepen knowledge of underlying biological mechanisms.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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