New Morphofunctional Criteria for Resistance Profile in Post-Traumatic Stress Disorder Models as Adrenal Dysfunction Trigger.

Autor: Kondashevskaya MV; Avtsyn Research Institute of Human Morphology, 117418, Moscow, Russia. marivladiko@mail.ru., Komel'kova MV; South Ural State University, 454080, Chelyabinsk, Russia.; Chelyabinsk State University, 454001, Chelyabinsk, Russia., Tseilikman VE; South Ural State University, 454080, Chelyabinsk, Russia., Tseilikman OB; South Ural State University, 454080, Chelyabinsk, Russia.; Chelyabinsk State University, 454001, Chelyabinsk, Russia., Artem'yeva KA; Avtsyn Research Institute of Human Morphology, 117418, Moscow, Russia., Aleksankina VV; Avtsyn Research Institute of Human Morphology, 117418, Moscow, Russia., Boltovskaya MN; Avtsyn Research Institute of Human Morphology, 117418, Moscow, Russia., Sarapul'tsev AP; South Ural State University, 454080, Chelyabinsk, Russia.; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, 620049, Yekaterinburg, Russia., Popkov PN; South Ural State Medical University, 454092, Chelyabinsk, Russia., Chereshneva MV; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, 620049, Yekaterinburg, Russia., Chereshnev VA; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, 620049, Yekaterinburg, Russia.
Jazyk: angličtina
Zdroj: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2021 Nov; Vol. 501 (1), pp. 192-196. Date of Electronic Publication: 2021 Dec 28.
DOI: 10.1134/S0012496621060028
Abstrakt: For the first time in modeling posttraumatic stress disorder (PTSD), we have described the morphofunctional state of adrenal glands in Wistar rats resistant and sensitive to predator stress (rodent fear of the predator). Despite the evident signs of adrenal dysfunction in both phenotypes, we have discovered the thickening of undifferentiated cell zone and high indices of functional activity of stem cells in resistant animals, suggesting ample adaptation. The most important data demonstrate the direct relationship between the reduction of corticosterone and testosterone levels and adrenal dysfunction in PTSD models. The study results allow considering the adrenal stem cells as potential therapeutic targets.
(© 2021. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
Externí odkaz: