A selective Cu II complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells.

Autor: Machado PHA; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Paixão DA; Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Lino RC; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., de Souza TR; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., de Souza Bontempo NJ; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Sousa LM; Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Van Petten de Vasconcelos Azevedo F; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Orsolin PC; Centro Universitário de Patos de Minas , Patos de Minas, MG, Brazil., Lima PMAP; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Martins IC; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., da Costa Guerra JF; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Teixeira SC; Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia , Uberlândia, MG, Brazil. samuel.teixeira@ufu.br., Araújo TG; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Goulart LR; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Morelli S; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., Guerra W; Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil., de Oliveira Júnior RJ; Instituto de Biotecnologia, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. oliveirajunior@ufu.br.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Dec 27; Vol. 11 (1), pp. 24450. Date of Electronic Publication: 2021 Dec 27.
DOI: 10.1038/s41598-021-03909-1
Abstrakt: The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an essential micronutrient and is important to tumor biology, Cu II complexes emerged as an alternative to chemotherapy; however, its biological properties need to be better understood. Thus, we report in vitro the antitumor effects of two Cu II complexes named [Cu(4-fh)(phen)(ClO 4 ) 2 ] (complex 1) and [Cu(4-nh)(phen)(ClO 4 ) 2 ]·H 2 O (complex 2), in which 4-fh = 4-fluorophenoxyacetic acid hydrazide; 4-nh = 4-nitrobenzoic hydrazide and phen = 1,10-phenanthroline. Both complexes presented cytotoxic activity against tumor cells, but only complex 1 showed significant selectivity. Complex 1 also induced DNA-damage, led to G0/G1 arrest and triggered apoptosis, which was initiated by an autophagy dysfunction. The significant in vitro selectivity and the action mechanism of complex 1 are noteworthy and reveal this prodrug as promising for anticancer therapy.
(© 2021. The Author(s).)
Databáze: MEDLINE
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