Association of Serum Magnesium with Blood Pressure in Patients with Hypertensive Crises: A Retrospective Cross-Sectional Study.

Autor: Onor IO; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Pharmacy, University Medical Center New Orleans, 2000 Canal Street, New Orleans, LA 70112, USA., Hill LM; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Famodimu MM; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Coleman MR; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Huynh CH; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Beyl RA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA., Payne CJ; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Johnston EK; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Okogbaa JI; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA., Gillard CJ; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Pharmacy, University Medical Center New Orleans, 2000 Canal Street, New Orleans, LA 70112, USA., Sarpong DF; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.; Center for Minority Health and Health Disparities Research and Education, College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Borghol A; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA.; Department of Pharmacy, University Medical Center New Orleans, 2000 Canal Street, New Orleans, LA 70112, USA., Okpechi SC; Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine and Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA., Norbert I; CardioRenal Research Group (CRRG), College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA., Sanne SE; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA., Guillory SG; Department of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2021 Nov 24; Vol. 13 (12). Date of Electronic Publication: 2021 Nov 24.
DOI: 10.3390/nu13124213
Abstrakt: The role of magnesium in blood pressure has been studied among hypertensive patients; however, there is a dearth of studies exploring the role of magnesium in hypertensive crises. The primary objective of this study was to evaluate the relationship between serum magnesium and blood pressure in patients with hypertensive crises. This was a single-center, retrospective, chart review, cross-sectional study of patients with hypertensive crises. Patients were included if they were eighteen years of age or older, with an international classification disease ninth revision (ICD-9) code of 401.9 (hypertensive crises: emergency or urgency) and a documented magnesium level on their electronic medical record. The primary outcome of the study was the correlation between serum magnesium and blood pressure (systolic blood pressure and diastolic blood pressure) in patients with hypertensive crises. Two hundred and ninety-three patients were included in the study. The primary outcome result showed that serum magnesium was positively correlated with systolic blood pressure (r = 0.143, p = 0.014), but not diastolic blood pressure. Conclusion: This study found a significant positive association between magnesium and systolic blood pressure, but not diastolic blood pressure, among patients with hypertensive crises. This positive association of serum magnesium with systolic blood pressure was maintained after adjusting for covariates. This study's findings suggest a potential role of magnesium in blood pressure among patients with hypertensive crises.
Databáze: MEDLINE