Whole-genome analysis of haemophilus influenzae invasive strains isolated from Campinas state University hospital. An epidemiological approach 2012 - 2019 and ancestor strains.

Autor:	Pereira RFC; Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil., Guarnieri JPO; Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil., da Silva CFM; Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil., Bernardes BG; Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil., Lancellotti M; Biotechnology Laboratory, LABIOTEC, Faculty of Pharmaceutical Sciences (FCF), Campinas State University UNICAM, São Paulo, SP, Brazil. Electronic address: mlancell@unicamp.br.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2022 Jan-Feb; Vol. 26 (1), pp. 101667. Date of Electronic Publication: 2021 Dec 24.
DOI:	10.1016/j.bjid.2021.101667
Abstrakt:	Thirteen Haemophylus influenzae invasive strains isolated from patients at Clinical Hospital of State University of Campinas, from May 2013 through August 2019, was submitted to Illumina genome sequencing HiSeq platform. Further in silico analysis of serogroup and Multi Locus Sequence Typing (MLST) from whole DNA sequencing had demonstrated the actual clonal distribution in the Campinas Metropolitan region. Thus, results showed the existence of a new ST Haemophilus influenzae found in the Brazilian territory and an increase of strains belonging to serogroup a (three strains also belonging to ST23). In conclusion, we observed an increase of non-typable H. influenzae (NTHi) and a strain involved in invasive diseases in the Campinas - São Paulo region after frequent detection of those serotypes and genotypes in other Brazilian regions. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2021 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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