Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy.

Autor:	Ebert SM; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.; Emmyon, Inc., Rochester, MN, USA., Rasmussen BB; Emmyon, Inc., Rochester, MN, USA.; Department of Nutrition, Metabolism and Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX, USA., Judge AR; Emmyon, Inc., Rochester, MN, USA.; Department of Physical Therapy, University of Florida, Gainesville, FL, USA., Judge SM; Department of Physical Therapy, University of Florida, Gainesville, FL, USA., Larsson L; Department of Physiology and Pharmacology, Karolinska, Stockholm, Sweden., Wek RC; Department of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA., Anthony TG; Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ, USA., Marcotte GR; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA., Miller MJ; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA., Yorek MA; Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.; Department of Internal Medicine, Iowa City VA Medical Center, Iowa City, IA, USA., Vella A; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.; Emmyon, Inc., Rochester, MN, USA., Volpi E; Department of Nutrition, Metabolism and Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX, USA., Stern JI; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Strub MD; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Ryan Z; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Talley JJ; Emmyon, Inc., Rochester, MN, USA., Adams CM; Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.; Emmyon, Inc., Rochester, MN, USA.; Department of Internal Medicine, Iowa City VA Medical Center, Iowa City, IA, USA.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2022 Apr 01; Vol. 152 (4), pp. 926-938.
DOI:	10.1093/jn/nxab440
Abstrakt:	Activating transcription factor 4 (ATF4) is a multifunctional transcription regulatory protein in the basic leucine zipper superfamily. ATF4 can be expressed in most if not all mammalian cell types, and it can participate in a variety of cellular responses to specific environmental stresses, intracellular derangements, or growth factors. Because ATF4 is involved in a wide range of biological processes, its roles in human health and disease are not yet fully understood. Much of our current knowledge about ATF4 comes from investigations in cultured cell models, where ATF4 was originally characterized and where further investigations continue to provide new insights. ATF4 is also an increasingly prominent topic of in vivo investigations in fully differentiated mammalian cell types, where our current understanding of ATF4 is less complete. Here, we review some important high-level concepts and questions concerning the basic biology of ATF4. We then discuss current knowledge and emerging questions about the in vivo role of ATF4 in one fully differentiated cell type, mammalian skeletal muscle fibers. (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
Databáze:	MEDLINE
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