Natural rodent model of viral transmission reveals biological features of virus population dynamics.

Autor:	Fay EJ; Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.; Center for Immunology, University of Minnesota, Minneapolis, MN., Balla KM; Department of Human Genetics, University of Utah, Salt Lake City, UT., Roach SN; Biochemistry, Molecular Biology and Biophysics Graduate Program, University of Minnesota, Minneapolis, MN.; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Shepherd FK; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Putri DS; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN., Wiggen TD; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Goldstein SA; Department of Human Genetics, University of Utah, Salt Lake City, UT., Pierson MJ; Center for Immunology, University of Minnesota, Minneapolis, MN., Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC., Thefaine CE; Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN., Tucker A; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Salnikov M; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Cortez V; Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA., Compton SR; Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT., Kotenko SV; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ., Hunter RC; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN., Masopust D; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.; Center for Immunology, University of Minnesota, Minneapolis, MN., Elde NC; Department of Human Genetics, University of Utah, Salt Lake City, UT., Langlois RA; Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.; Center for Immunology, University of Minnesota, Minneapolis, MN.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2022 Feb 07; Vol. 219 (2). Date of Electronic Publication: 2021 Dec 27.
DOI:	10.1084/jem.20211220
Abstrakt:	Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty" mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics of murine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis. Competing Interests: Disclosures:   S.V. Kotenko reported a patent to IFN-λ polypeptides and compositions issued, a patent to IFN-λ1 polypeptides issued, a patent to method for increasing IFN activity in an individual issued, a patent to methods for increasing levels of IFN activity with an IFN-λ3 polypeptide issued, and a patent to type I and type III IFN fusion molecules and methods for use thereof pending. No other disclosures were reported. (© 2021 Fay et al.)
Databáze:	MEDLINE
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