Moderate alcohol consumption and lipoprotein subfractions: a systematic review of intervention and observational studies.

Autor:	Wilkens TL; Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Denmark., Tranæs K; Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Denmark., Eriksen JN; Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Denmark., Dragsted LO; Department of Nutrition, Exercise and Sports, Section for Preventive and Clinical Nutrition, University of Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Nutrition reviews [Nutr Rev] 2022 Apr 08; Vol. 80 (5), pp. 1311-1339.
DOI:	10.1093/nutrit/nuab102
Abstrakt:	Context: Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions. Objective: To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms. Data Sources: Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases. Data Extraction: A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies. Results: Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B-containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies. Conclusions: Up to 60 g/d alcohol can cause changes in lipoprotein subfractions and related mechanisms that could influence cardiovascular health. Systematic Review Registration: PROSPERO registration no. 98955. (© The Author(s) 2021. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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