Sensitivity of a Subject-specific Ankle Sprain Simulation to Extrinsic Versus Intrinsic Biomechanical Factors.

Autor:	Yoder AJ; DoD-VA Extremity Trauma and Amputation Center of Excellence, San Diego, CA, United States.; Department of Physical and Occupational Therapy, Naval Medical Center, San Diego, CA, United States., Petrella AJ; Department of Mechanical Engineering, Colorado School of Mines, Golden, CO, United States., Farrokhi S; DoD-VA Extremity Trauma and Amputation Center of Excellence, San Diego, CA, United States.; Department of Physical and Occupational Therapy, Naval Medical Center, San Diego, CA, United States.; Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2021 Dec 08; Vol. 9, pp. 765331. Date of Electronic Publication: 2021 Dec 08 (Print Publication: 2021).
DOI:	10.3389/fbioe.2021.765331
Abstrakt:	Ankle sprains are the most common musculoskeletal injury in sport and military activity, despite existing prophylactic strategies. The purpose of this report was to develop a probabilistic simulation of lateral ankle sprains during single-limb drop landing, towards accelerating innovation in ankle sprain prevention. A deterministic, subject-specific musculoskeletal model was extended with automation and probabilistic distributions on sprain-related biomechanical factors. Probabilistic simulations were generated using traditional Monte Carlo techniques and the advanced mean value method, a more computationally-efficient approach. Predicted distributions of peak ankle joint rotations, velocities, and moments borne by supporting passive structures agreed favorably with the deterministic model and with reports of real sprain biomechanics. Parameter sensitivities identified that predictions were most strongly influenced by drop height, subtalar joint posture at contact, invertor/evertor co-activation, and passive ankle stiffness. The advanced mean value method predicted confidence bounds comparable to a 1000-trial Monte Carlo simulation, and required only 14 model evaluations and 4-min processing time. The extended probabilistic simulation may be useful to virtually test new prophylactic strategies for ankle sprains, and is made available for open-source use (https://simtk.org/projects/sprain-sim). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Yoder, Petrella and Farrokhi.)
Databáze:	MEDLINE
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