Haemoglobin A1c-based screening for prediabetes and diabetes mellitus: a multi-center study in Croatian adult population.
| Autor: | Lapić I; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia., Rogić D; Department of Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia.; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Nikolac Gabaj N; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.; Department for Clinical Chemistry, University Clinical Hospital Sestre milosrdnice, Zagreb, Croatia., Kajić K; Laboratory for Medical Biochemistry, General Hospital Bjelovar, Bjelovar, Croatia., Peran N; Department of Laboratory Diagnostics, General Hospital of Šibenik-Knin County, Šibenik, Croatia., Surjan L; Department of Laboratory Diagnostics, General Hospital of Šibenik-Knin County, Šibenik, Croatia., Đuras A; Laboratory for Medical Biochemistry, General Hospital Varaždin, Varaždin, Croatia., Cesar Kocijan V; Laboratory for Medical Biochemistry, General Hospital Varaždin, Varaždin, Croatia., Bilopavlović N; Department of Medical Laboratory Diagnostics, University Hospital Center Split, Split, Croatia., Smaić F; Department of Laboratory Diagnostics, General Hospital 'Dr Josip Benčević', Slavonski Brod, Croatia., Štefanović M; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.; Department for Clinical Chemistry, University Clinical Hospital Sestre milosrdnice, Zagreb, Croatia., Ostroški I; Laboratory for Medical Biochemistry, General Hospital Varaždin, Varaždin, Croatia., Tandara L; Department of Medical Laboratory Diagnostics, University Hospital Center Split, Split, Croatia., Krnjaić-Tadijanović M; Department of Laboratory Diagnostics, General Hospital 'Dr Josip Benčević', Slavonski Brod, Croatia., Gornik I; Department of Emergency Medicine, University Hospital Center Zagreb, Zagreb, Croatia., Pintarić H; Emergency Department, University Clinical Hospital Sestre milosrdnice, Zagreb, Croatia.; School of Dental Medicine, University of Zagreb, Zagreb, Croatia., Marasović Krstulović D; Internal Clinic, University Hospital Center Split, Split, Croatia., Miškić B; Department for Internal Medicine, General Hospital 'Dr Josip Benčević', Slavonski Brod, Croatia., Rahelić D; Department of Diabetes and Endocrinology, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia. |
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| Jazyk: | angličtina |
| Zdroj: | Biochemia medica [Biochem Med (Zagreb)] 2022 Feb 15; Vol. 32 (1), pp. 010903. Date of Electronic Publication: 2021 Dec 15. |
| DOI: | 10.11613/BM.2022.010903 |
| Abstrakt: | Introduction: Based on the hypothesis that there is a substantial rate of adults with prediabetes and undiagnosed diabetes mellitus (DM), our aim was to perform haemoglobin A1c (HbA Materials and Methods: This multi-center, cross-sectional study performed in six Croatian hospitals included 5527 patients aged 40 to 70 years admitted to the Emergency Department or undergoing a primary care check-up. Haemoglobin A1c was measured from leftover whole blood samples using the enzymatic method on either Alinity c or Architect c-series analyser (Abbott Laboratories, Chicago, USA). Haemoglobin A1c between 39-47 mmol/mol was classified as prediabetes, while ≥ 48 mmol/mol as undiagnosed DM. Results: After exclusion of 435 patients with known DM, the final cohort included 5092 patients (median age 57; 56% males). A total of 882 (17.3%) patients had HbA Conclusion: Underlying impairment of glucose metabolism was identified in about one in five adults, with significant number of patients with already overt DM. These results should serve as a starting point for further steps directed towards promotion of preventive measures for DM in Croatia. Competing Interests: Potential conflict of interest None declared. (Croatian Society of Medical Biochemistry and Laboratory Medicine.) |
| Databáze: | MEDLINE |
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