Plasmolipin and Its Role in Cell Processes.

Autor: Shulgin AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Moscow Institute of Physics and Technology (State University), 141701 Dolgoprudny, Moscow oblast Russia., Lebedev TD; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Prassolov VS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Spirin PV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: Molecular biology [Mol Biol] 2021; Vol. 55 (6), pp. 773-785. Date of Electronic Publication: 2021 Dec 17.
DOI: 10.1134/S0026893321050113
Abstrakt: The mechanisms involved in the origin and development of malignant and neurodegenerative diseases are an important area of modern biomedicine. A crucial task is to identify new molecular markers that are associated with rearrangements of intracellular signaling and can be used for prognosis and the development of effective treatment approaches. The proteolipid plasmolipin (PLLP) is a possible marker. PLLP is a main component of the myelin sheath and plays an important role in the development and normal function of the nervous system. PLLP is involved in intracellular transport, lipid raft formation, and Notch signaling. PLLP is presumably involved in various disorders, such as cancer, schizophrenia, Alzheimer's disease, and type 2 diabetes mellitus. PLLP and its homologs were identified as possible virus entry receptors. The review summarizes the data on the PLLP structure, normal functions, and role in diseases.
Competing Interests: Conflict of interests. The authors declare that they have no conflict of interest.
(© The Author(s) 2021, ISSN 0026-8933, Molecular Biology, 2021, Vol. 55, No. 6, pp. 773–785. © The Author(s), 2021. This article is an open access publication.Russian Text © The Author(s), 2021, published in Molekulyarnaya Biologiya, 2021, Vol. 55, No. 6, pp. 883–896.)
Databáze: MEDLINE
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