Specialized pro-resolving mediators in respiratory diseases.

Autor:	Cagnina RE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital., Duvall MG; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital.; Division of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Nijmeh J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital., Levy BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital.
Jazyk:	angličtina
Zdroj:	Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2022 Mar 01; Vol. 25 (2), pp. 67-74.
DOI:	10.1097/MCO.0000000000000805
Abstrakt:	Purpose of Review: Persistent unresolved inflammation results in a number of pathologic respiratory diseases including asthma, cystic fibrosis, acute respiratory distress syndrome (ARDS) and coronavirus disease 2019 (COVID-19)-associated ARDS. Inflammation resolution is an active series of biologic processes orchestrated by a family of bioactive specialized pro-resolving mediators (SPMs) derived from essential omega-3 and omega-6 polyunsaturated fatty acids (PUFAs). In this review, we highlight recent findings on dysregulated inflammation resolution in common respiratory diseases and recent literature on SPM generation with PUFA dietary supplementation with relevance to diseases of respiratory inflammation. Recent Findings: Human studies and preclinical models of diseases of lung inflammation have revealed disequilibrium in the levels of pro-inflammatory versus pro-resolving mediators. Recent studies identified actions for SPMs on regulating prophlogistic host responses and stimulating inflammation resolution pathways in inflammatory respiratory diseases. Summary: Dietary marine oils are enriched in PUFAs and contain parent omega-3 and omega-6 fatty acids and precursors for conversion to SPMs. Nutritional supplementation with fish oils can boost SPM levels and offer a therapeutic approach targeting inflammation resolution pathways for diseases of lung inflammation. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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