Early-life seizures modify behavioral response to ultrasonic vocalization playback in adult rats.

Autor: Bigelow LJ; University of Prince Edward Island, Biomedical Sciences, Charlottetown, PE, Canada., Fiset C; University of Prince Edward Island, Biomedical Sciences, Charlottetown, PE, Canada., Jarvis JHM; University of Prince Edward Island, Biomedical Sciences, Charlottetown, PE, Canada., Macleod S; University of Prince Edward Island, Biomedical Sciences, Charlottetown, PE, Canada., Wöhr M; KU Leuven, Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, B-3000 Leuven, Belgium; KU Leuven, Leuven Brain Institute, B-3000 Leuven, Belgium; Behavioral Neuroscience, Experimental and Biological Psychology, Faculty of Psychology, Philipps University of Marburg, Gutenbergstr. 18, D-35032 Marburg, Germany; Center for Mind, Brain and Behavior, Philipps-University of Marburg, Hans-Meerwein-Str. 6, D-35032 Marburg, Germany., Benke TA; University of Colorado School of Medicine, Department of Pediatrics, Aurora, CO, United States., Bernard PB; University of Prince Edward Island, Biomedical Sciences, Charlottetown, PE, Canada. Electronic address: pbernard@upei.ca.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2022 Feb; Vol. 127, pp. 108494. Date of Electronic Publication: 2021 Dec 23.
DOI: 10.1016/j.yebeh.2021.108494
Abstrakt: Early-life seizures (ELS) are associated with autism spectrum disorder (ASD); however, due to a lack of effective treatments for ELS, it is not clear whether ELS plays a causal role, potentiates the ASD phenotype, or is the result of a common pathophysiology. Deficits in communications are a core feature of ASD. To isolate the impact of ELS on communication, we probed the behavioral consequences of a single episode of kainic acid-induced early-life seizures (KA-ELS) in male and female Sprague-Dawley (CD) rats. Deficits in auditory communication were observed in adult male rats as assessed by behavioral response to ultrasonic vocalization (USV) playback. Ultrasonic vocalizations are classified into two major categories - 50-kHz (positive) calls and 22-kHz (aversive) calls. Behavioral response was assessed via rat preference for different USV playback in a radial arm maze. Response to 22-kHz calls was not impacted by ELS while response to 50-kHz calls was impacted. All rats demonstrated positional preference for the arms adjacent to where 50-kHz calls were playing compared to background noise; however, male ELS rats demonstrated a greater positional preference for the arms adjacent to where 50-kHz calls were playing compared to male control rats. These studies demonstrate that responses to socially relevant auditory cues are chronically altered in adult male rats following a single episode of ELS. We speculate that these changes contribute to previously reported social deficits associated with ELS.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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