Association of F 2 -isoprostane levels with Alzheimer's disease in observational studies: A systematic review and meta-analysis.

Autor: Trares K; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115 Heidelberg, Germany; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120 Heidelberg., Chen LJ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany., Schöttker B; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115 Heidelberg, Germany; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: b.schoettker@dkfz.de.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2022 Feb; Vol. 74, pp. 101552. Date of Electronic Publication: 2021 Dec 24.
DOI: 10.1016/j.arr.2021.101552
Abstrakt: Introduction: The association between F 2 -isoprostanes and Alzheimer's disease (AD) has been controversially discussed in the literature since the 1990s. However, no systematic review has been performed so far.
Methods: A systematic review of observational studies on the associations of F 2 -isoprostanes and the specific biomarker 8-iso-prostaglandin F 2α with AD were conducted. Random-effects model meta-analyses were performed.
Results: 29 studies were included in the systematic review, including four longitudinal studies. In an overall meta-analysis of the 25 cross-sectional studies, F 2 -isoprostane levels were statistically significantly associated with AD (Hedge's g [95% confidence interval]: 1.00 [0.69-1.32]). When studies were grouped by biomarker and sample specimen, F 2 -isoprostane and 8-iso-prostaglandin F 2α levels were statistically significantly elevated in tissue samples of the frontal lobe of AD patients. Moreover, F 2 -isoprostane levels in cerebrospinal fluid and 8-iso-prostaglandin F 2α levels in blood samples of AD patients were significantly increased. Meta-analyses of the few longitudinal studies did not reach statistical significance.
Discussion: Increased concentrations of F 2 -isoprostanes were found in AD patients. However, due to the lack of adjustment in most cross-sectional case-control studies, results must be interpreted carefully. In addition, the causality of the association is uncertain because evidence from well-conducted longitudinal studies was conflicting, and further longitudinal studies are required to reinforce the results.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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