Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3.

Autor: Balleza-Tapia H; Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden. Electronic address: h.bllz.tp@gmail.com., Arroyo-García LE; Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden., Isla AG; Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden., Loera-Valencia R; Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden., Fisahn A; Neuronal Oscillations Laboratory, Division of Neurogeriatrics, Center for Alzheimer Research, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 17164, Solna, Sweden. Electronic address: andre.fisahn@ki.se.
Jazyk: angličtina
Zdroj: Progress in neurobiology [Prog Neurobiol] 2022 Mar; Vol. 210, pp. 102213. Date of Electronic Publication: 2021 Dec 24.
DOI: 10.1016/j.pneurobio.2021.102213
Abstrakt: Gamma oscillations (γ-oscillations) in hippocampal area CA3 are essential for memory function. Particularly, CA3 is involved in the memory related process pattern completion, which is linked with the γ-oscillations in human hippocampus. Recent studies suggest that heterogeneity in the functional properties of pyramidal cells (PCs) in CA3 plays an important role in hippocampal function. By performing concomitant recordings of PC activity and network γ-oscillations in CA3 we found three functionally-different PC subpopulations. PCs with high spike-frequency adaptation (hA PC ) have the strongest action potential gamma phase-coupling, PCs with low adaptation (lA PC ) show lower phase-coupling and PCs displaying a burst-firing pattern (B PC ) remained quiescent. In addition, we discovered that hA PC display the highest excitatory/inhibitory drive, followed by lA PC , and lastly B PC . In conclusion, our data advance the hypothesis that PCs in CA3 are organized into subpopulations with distinct functional roles for cognition-relevant network dynamics and provide new insights in the physiology of hippocampus.
(Copyright © 2021. Published by Elsevier Ltd.)
Databáze: MEDLINE
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