Onset of oral lichen planus following dental treatments: A nested case-control study.

Autor: Ma KS; Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Dentistry, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung, Taiwan.; Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan., Thota E; Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan., Huang JY; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan., Huang YF; Department of Dentistry, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung, Taiwan.; College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan., Wei JC; Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2023 Apr; Vol. 29 (3), pp. 1269-1281. Date of Electronic Publication: 2022 Feb 01.
DOI: 10.1111/odi.14115
Abstrakt: Introduction: The exposure to amalgam restorations has been reported to bring about altered immunity followed by inflammation and infection.
Aims: This study aimed at identifying whether patients who received restorative or endodontic treatments, or tooth extraction, would have altered odds of developing oral lichen planus (OLP).
Material and Methods: In this population-based nested case-control study, 421 cases of OLP and 1,684 controls were included after propensity score matching. Logistic regression was used to estimate the adjusted odds ratio (aOR) of OLP in individuals who had received amalgam and composite resin restorations, root canal therapy, and tooth extraction over a follow-up duration of five years.
Results: There were no significantly different odds of OLP for those who underwent either amalgam (aOR = 0.948, 95% CI = 0.853-1.053, p = 0.3170) or resin restorations (aOR = 1.007, 95% CI = 0.978-1.037, p = 0.6557) in both anterior and posterior teeth in an observational period of five  years after restorations. Root canal therapy was associated with significantly lower odds of OLP, with each additional root canal therapy attenuating the risk of OLP at an aOR of 0.771 (95% CI = 0.680-0.874, p = 0.0001) for both anterior (aOR = 0.786, 95% CI = 0.626-0.986, p = 0.0372) and posterior teeth (aOR = 0.762, 95% CI = 0.650-0.893, p = 0.0008). Likewise, each tooth extraction reduced the risk of OLP, with an aOR of 0.846 (95% CI = 0.772-0.927, p = 0.0003), especially for anterior teeth (aOR = 0.733, 95% CI = 0.595-0.904, p = 0.0037).
Conclusions: We reported no significant association between dental restorations and consequent OLP, and significantly lower odds of OLP following both root canal therapy and tooth extraction.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: