Influence of gonadal steroids on cortical surface area in infancy.

Autor:	Alex AM; Neuroengineering Division, Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA., Ruvio T; Neuroengineering Division, Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA., Xia K; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA., Jha SC; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Girault JB; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.; Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Wang L; Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Li G; Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Shen D; School of Biomedical Engineering, ShanghaiTech University, Shanghai 201210, China.; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea., Cornea E; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA., Styner MA; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gilmore JH; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA., Knickmeyer RC; Neuroengineering Division, Institute for Quantitative Health Sciences and Engineering, Michigan State University, East Lansing, MI 48824, USA.; Department of Psychiatry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA.; Center for Research in Autism, Intellectual, and Other Neurodevelopmental Disabilities, Michigan State University, East Lansing, MI 48824, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 Jul 21; Vol. 32 (15), pp. 3206-3223.
DOI:	10.1093/cercor/bhab410
Abstrakt:	Sex differences in the human brain emerge as early as mid-gestation and have been linked to sex hormones, particularly testosterone. Here, we analyzed the influence of markers of early sex hormone exposure (polygenic risk score (PRS) for testosterone, salivary testosterone, number of CAG repeats, digit ratios, and PRS for estradiol) on the growth pattern of cortical surface area in a longitudinal cohort of 722 infants. We found PRS for testosterone and right-hand digit ratio to be significantly associated with surface area, but only in females. PRS for testosterone at the most stringent P value threshold was positively associated with surface area development over time. Higher right-hand digit ratio, which is indicative of low prenatal testosterone levels, was negatively related to surface area in females. The current work suggests that variation in testosterone levels during both the prenatal and postnatal period may contribute to cortical surface area development in female infants. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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