Noninvasive estimation of human radiation dosimetry of 18 F-FDG by whole-body small animal PET imaging in rats.

Autor: Shidahara M; Division of Applied Quantum Medical Engineering, Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Japan. Electronic address: miho.shidahara.c2@tohoku.ac.jp., Funaki Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan., Watabe H; Division of Radiation Protection and Safety Control, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2022 Mar; Vol. 181, pp. 110071. Date of Electronic Publication: 2021 Dec 17.
DOI: 10.1016/j.apradiso.2021.110071
Abstrakt: Purpose: Small animal PET provides the biodistribution of administrated radiotracer in vivo and have a potential to contribute on dosimetry study. The aim of this study is to investigate the effect of region-of-interest (ROI)-delineation in whole-body rat PET image toward non-invasive estimation of human dosimetry of 18 F-FDG.
Method: After administration of 18 F-FDG (averaged 11.7 MBq), 3.5-h PET and 20-min CT scans were sequentially performed for three rats by Clairvivo PET/CT system. Seven source organs, and the remainder of the body, were studied to extrapolate %ID(t) and estimate time-integrated activity coefficients [kBq-h/MBq] in human. The mean absorbed dose in each target organ and the effective dose were estimated by MIRD method. Effects of ROI-definitions on both extrapolated %ID(t) in human and estimated doses were also investigated by using (i) small ROIs of high uptake region and (ii) whole organ ROIs.
Results: Averaged effective doses of 18 F-FDG in human by using high-uptake and whole-organ ROIs were 27.8 ± 6.54 and 19.3 ± 2.72 μSv/MBq, respectively.
Conclusion: The use of small animal PET scanner, which allows repeatedly PET scans, have a potential to contribute on the reduction of the number of experimental animals. However, the ways of ROI drawing influences on the estimated effective dose and safe-side ROI definition may be preferred.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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