Corticospinal Tract Lesion Load Originating From Both Ventral Premotor and Primary Motor Cortices Are Associated With Post-stroke Motor Severity.

Autor: Ito KL; Division of Occupational Science and Occupational Therapy, Herman Ostrow School of Dentistry, 5116University of Southern California, Los Angeles, CA, USA., Kim B; Department of Physical Therapy Education, College of Health Professions, 12302SUNY Upstate Medical University, Syracuse, NY, USA., Liu J; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, 117865Tianjin Medical University General Hospital, Tianjin, China., Soekadar SR; Clinical Neurotechnology Laboratory, Dept. of Psychiatry and Neurosciences (CCM), Charité - Universitätsmedizin Berlin, Berlin, Germany., Winstein C; Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, 12222University of Southern California, Los Angeles, CA, USA.; Department of Neurology, Keck School of Medicine, 12222University of Southern California, Los Angeles, CA, USA., Yu C; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, 117865Tianjin Medical University General Hospital, Tianjin, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Cramer SC; Department of Neurology, UCLA; 12222California Rehabilitation Institute, Los Angeles, CA, USA., Schweighofer N; Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, 12222University of Southern California, Los Angeles, CA, USA., Liew SL; Division of Occupational Science and Occupational Therapy, Herman Ostrow School of Dentistry, 5116University of Southern California, Los Angeles, CA, USA.; Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, 12222University of Southern California, Los Angeles, CA, USA.; Department of Neurology, Keck School of Medicine, 12222University of Southern California, Los Angeles, CA, USA.
Jazyk: angličtina
Zdroj: Neurorehabilitation and neural repair [Neurorehabil Neural Repair] 2022 Mar; Vol. 36 (3), pp. 179-182. Date of Electronic Publication: 2021 Dec 24.
DOI: 10.1177/15459683211068441
Abstrakt: Lesion load of the corticospinal tract (CST-LL), a measure of overlap between a stroke lesion and the CST, is one of the strongest predictors of motor outcomes following stroke. CST-LL is typically calculated by using a probabilistic map of the CST originating from the primary motor cortex (M1). However, higher order motor areas also have projections that contribute to the CST and motor control. In this retrospective study, we examined whether evaluating CST-LL from additional motor origins is more strongly associated with post-stroke motor severity than using CST-LL originating from M1 only. We found that lesion load to both the ventral premotor (PMv) cortex and M1 were more strongly related to stroke motor severity indexed by Fugl-Meyer Assessment cut-off scores than CST-LL of M1 alone, suggesting that higher order motor regions add clinical relevance to motor impairment.
Databáze: MEDLINE