[Current diagnostic methods in molecular classification of brain tumors at the Burdenko Neurosurgical Center].

Autor:	Ryzhova MV; Burdenko Neurosurgical Center, Moscow, Russia., Telysheva EN; Burdenko Neurosurgical Center, Moscow, Russia., Shaikhaev EG; Burdenko Neurosurgical Center, Moscow, Russia., Starovoitov DV; Burdenko Neurosurgical Center, Moscow, Russia., Kotelnikova AO; Burdenko Neurosurgical Center, Moscow, Russia., Galstyan SA; Burdenko Neurosurgical Center, Moscow, Russia., Okonechnikov KV; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jazyk:	ruština
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2021; Vol. 85 (6), pp. 98-101.
DOI:	10.17116/neiro20218506198
Abstrakt:	DnA methylation has recently been accepted as the most reliable and effective method of diagnosing central nervous system (CNS) tumors. Healthy organs and tumors of different localizations have their own unique methylation structure. Determination of total tumor DNA methylome is the detection of all methylated nucleotides in a tumor. The "gold standard" for analyzing the methylation state of individual cytosines is bisulfite conversion, in which unmethylated cytosines are converted to uracils and read as thymines, while methylated cytosines are protected from conversion.
Databáze:	MEDLINE
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