VEGF Expression, Cellular Infiltration, and Intratumoral Collagen Levels after Electroporation-Based Treatment of Dogs with Cutaneous Squamous Cell Carcinoma.

Autor: Dos Anjos D; Department of Veterinary Clinic and Surgery, São Paulo State University, Jaboticabal 14884-900, Brazil., Bueno C; Department of Veterinary Clinic and Surgery, São Paulo State University, Jaboticabal 14884-900, Brazil., Mattos-Junior E; Department of Veterinary Surgery and Animal Anesthesiology, University of Franca, Franca 14404-600, Brazil., De Nardi AB; Department of Veterinary Clinic and Surgery, São Paulo State University, Jaboticabal 14884-900, Brazil., Fonseca-Alves CE; Department of Veterinary Surgery and Animal Anesthesiology, São Paulo State University-UNESP, Botucatu 18618-681, Brazil.; Institute of Health Sciences, Bauru Campus, Paulista University-UNIP, Bauru 17048-290, Brazil.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2021 Nov 30; Vol. 11 (12). Date of Electronic Publication: 2021 Nov 30.
DOI: 10.3390/life11121321
Abstrakt: Canine cutaneous squamous cell carcinoma (SCC) is the most common type of skin cancer in tropical countries and is generally associated with exposure to solar ultraviolet light. It has a low metastatic rate, and local treatments, such as electrochemotherapy (ECT), promote long-term control or even complete remission. This study aimed to evaluate pre- and post-ECT treatment expression levels of vascular endothelial growth factor (VEGF) and CD31, cellular infiltration, and intratumoral collagen levels in dogs with cutaneous SCC. A prospective nonrandomized clinical study was performed using dogs with spontaneous SCC treated with ECT. Eighteen lesions from 11 dogs were included in the study. The expression levels of VEGF and CD31; cellular infiltration; and intratumoral collagen levels, as determined by Masson's trichrome staining, were not significantly different from pre-treatment measurements on day 21 ( p > 0.05). However, among cellular infiltration, the mixed subtype was correlated with better overall survival time when compared to lymphoplasmacytic and neutrophilic infiltration ( p < 0.05). In conclusion, ECT had no effect on VEGF expression, cellular infiltration, or intratumoral collagen levels in dogs with cutaneous SCC at the time of evaluation, suggesting that early and late post-ECT-treatment phases should be considered.
Databáze: MEDLINE
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