Weaving Mitochondrial DNA and Y-Chromosome Variation in the Panamanian Genetic Canvas.

Autor: Rambaldi Migliore N; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Colombo G; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Capodiferro MR; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Mazzocchi L; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Chero Osorio AM; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Raveane A; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.; Laboratory of Hematology-Oncology, European Institute of Oncology IRCCS, 20141 Milan, Italy., Tribaldos M; Gorgas Memorial Institute for Health Studies, Panama City 0816-02593, Panama., Perego UA; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.; Department of Math and Science, Southeastern Community College, West Burlington, IA 52655, USA., Mendizábal T; Center for Historical, Anthropological and Cultural Research-AIP, Panama City 0816-07812, Panama.; Smithsonian Tropical Research Institute, Panama City 0843-03092, Panama., Montón AG; Departamento de Geografía, Historia y Filosofía, Universidad Pablo de Olavide, 41013 Seville, Spain., Lombardo G; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Grugni V; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Garofalo M; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Ferretti L; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Cereda C; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Gagliardi S; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Cooke R; Smithsonian Tropical Research Institute, Panama City 0843-03092, Panama.; Sistema Nacional de Investigadores, Secretaría Nacional de Ciencia y Tecnología, Ciudad del Saber, Clayton 0816-02852, Panama., Smith-Guzmán N; Smithsonian Tropical Research Institute, Panama City 0843-03092, Panama.; Sistema Nacional de Investigadores, Secretaría Nacional de Ciencia y Tecnología, Ciudad del Saber, Clayton 0816-02852, Panama., Olivieri A; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Aram B; Departamento de Geografía, Historia y Filosofía, Universidad Pablo de Olavide, 41013 Seville, Spain., Torroni A; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Motta J; Gorgas Memorial Institute for Health Studies, Panama City 0816-02593, Panama., Semino O; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy., Achilli A; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, 27100 Pavia, Italy.
Jazyk: angličtina
Zdroj: Genes [Genes (Basel)] 2021 Nov 29; Vol. 12 (12). Date of Electronic Publication: 2021 Nov 29.
DOI: 10.3390/genes12121921
Abstrakt: The Isthmus of Panama was a crossroads between North and South America during the continent's first peopling (and subsequent movements) also playing a pivotal role during European colonization and the African slave trade. Previous analyses of uniparental systems revealed significant sex biases in the genetic history of Panamanians, as testified by the high proportions of Indigenous and sub-Saharan mitochondrial DNAs (mtDNAs) and by the prevalence of Western European/northern African Y chromosomes. Those studies were conducted on the general population without considering any self-reported ethnic affiliations. Here, we compared the mtDNA and Y-chromosome lineages of a new sample collection from 431 individuals (301 males and 130 females) belonging to either the general population, mixed groups, or one of five Indigenous groups currently living in Panama. We found different proportions of paternal and maternal lineages in the Indigenous groups testifying to pre-contact demographic events and genetic inputs (some dated to Pleistocene times) that created genetic structure. Then, while the local mitochondrial gene pool was marginally involved in post-contact admixtures, the Indigenous Y chromosomes were differentially replaced, mostly by lineages of western Eurasian origin. Finally, our new estimates of the sub-Saharan contribution, on a more accurately defined general population, reduce an apparent divergence between genetic and historical data.
Databáze: MEDLINE
Externí odkaz: