| Autor: |
Baimenov AZ; National Laboratory Astana, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.; Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050012, Kazakhstan., Fakhradiyev IR; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, School of Pharmacy, Kazakh National Medical University, Almaty 050012, Kazakhstan., Berillo DA; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, School of Pharmacy, Kazakh National Medical University, Almaty 050012, Kazakhstan., Saliev T; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, School of Pharmacy, Kazakh National Medical University, Almaty 050012, Kazakhstan., Mikhalovsky SV; Department of Chemisorption and Hybrid Materials, Chuiko Institute of Surface Chemistry, 03164 Kyiv, Ukraine.; ANAMAD Ltd., Brighton BN1 9SB, UK., Nurgozhin TS; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, School of Pharmacy, Kazakh National Medical University, Almaty 050012, Kazakhstan., Inglezakis VJ; Department of Chemical & Process Engineering, University of Strathclyde, Glasgow G1 1XJ, UK. |
| Abstrakt: |
The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscopy. The use of the cryogel in the treatment of rats administered an LD 50 dose of Cd(NO 3 ) 2 , CsNO 3 , Sr(NO 3 ) 2 , or HgCl 2 in aqueous solution showed their high survival rate compared to the control group, which did not receive such treatment. The histological and chemical analysis of internal tissues and the biochemical analysis of the blood of the experimental animals showed the effectiveness of the cryogel in protecting the animals against the damaging effect of HMs on the organism comparable with unithiol, a chelating agent based on 2,3-dimercapto-1-propane sulfonic acid sodium salt (DMPS) approved for the treatment of acute poisoning with some heavy metals. |
