| Autor: |
Chis AF; Department of Pneumology, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, 8th Victor Babeș Street, 400012 Cluj, Romania.; 'Leon Daniello' Clinical Hospital of Pneumology, 6th Bogdan Petriceicu Hașdeu Street, 400332 Cluj, Romania., Râjnoveanu RM; Department of Pneumology, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, 8th Victor Babeș Street, 400012 Cluj, Romania.; 'Leon Daniello' Clinical Hospital of Pneumology, 6th Bogdan Petriceicu Hașdeu Street, 400332 Cluj, Romania., Man MA; Department of Pneumology, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, 8th Victor Babeș Street, 400012 Cluj, Romania.; 'Leon Daniello' Clinical Hospital of Pneumology, 6th Bogdan Petriceicu Hașdeu Street, 400332 Cluj, Romania., Todea DA; Department of Pneumology, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, 8th Victor Babeș Street, 400012 Cluj, Romania.; 'Leon Daniello' Clinical Hospital of Pneumology, 6th Bogdan Petriceicu Hașdeu Street, 400332 Cluj, Romania., Chis BA; 2nd Department of Internal Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 8th Victor Babeș Street, 400012 Cluj, Romania., Stancu B; 2nd Department of General Surgery, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 8th Victor Babeș Street, 400012 Cluj, Romania., Arghir IA; 4th Department of Clinical Medical Disciplines II, 'Ovidius' University of Medicine and Pharmacy, Mamaia Boulevard, No. 124, 900527 Constanța, Romania., Alexescu TG; 5th Departament Internal Medicine, 4th Medical Clinic, University of Medicine and Pharmacy, 400015 Cluj, Romania., Pop CM; Department of Pneumology, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, 8th Victor Babeș Street, 400012 Cluj, Romania.; 'Leon Daniello' Clinical Hospital of Pneumology, 6th Bogdan Petriceicu Hașdeu Street, 400332 Cluj, Romania. |
| Abstrakt: |
Background and Objectives : Chronic obstructive pulmonary disease (COPD) represents a debilitating disease, with rising morbidity and mortality. Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, vascular permeability, and airway remodeling. The purpose of this study was to investigate the relationship between VEGF serum levels and VEGF +936 C/T gene polymorphism (rs3025039) with COPD, for the first time in a Romanian population. Materials and Methods : In total, 120 participants from Transylvania were included in this case-control study. Serum levels of VEGF were determined using an enzyme-linked immune-sorbent assay and rs3025039 was investigated by high molecular weight genomic deoxyribonucleic acid (DNA). Spirometric values, arterial blood gas analysis, and the Six Minute Walk Test (6MWT) outcome were also determined. Results : The serum level of VEGF was higher in the COPD group versus controls ( p < 0.001), with a positive correlation with the 6MWT outcome. No significant difference was observed in the VEGF serum levels between VEGF +936C/T genotypes. There was no difference in the VEGF +936C/T genotype between COPD patients and healthy subjects (chi2 test p = 0.92, OR = 1.04, 95%CI = 0.41-2.62), but the presence of the T allele was significantly linked to the presence of COPD (chi2 test p = 0.02, OR = 2.36, 95%CI = 1.12-4.97). Conclusions : Higher VEGF serum levels were found in moderate and severe COPD and were positively correlated with the distance in the 6MWT. No significant difference was found between CC, CT, and TT genotypes of rs3025039 and the presence of COPD. The presence of the T allele was found to be linked to COPD and also to the degree of airway obstruction. |
