| Autor: |
Urbano-Gámez JD; Electronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain., Valdés-Sánchez L; Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain., Aracil C; Electronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain., de la Cerda B; Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain., Perdigones F; Electronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain., Plaza Reyes Á; Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain., Díaz-Corrales FJ; Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Avda. Américo Vespucio 24, 41092 Seville, Spain., Relimpio López I; RETICS Oftared, Carlos III Institute of Health (Spain), Ministry of Health RD16/0008/0010, University Hospital Virgen Macarena, Avda. Dr. Fedriani, 3, 41009 Seville, Spain., Quero JM; Electronic Technology Group, Department of Electronic Engineering, Higher Technical School of Engineering, University of Seville, Avda. de los Descubrimientos sn, 41092 Seville, Spain. |
| Abstrakt: |
Printed circuit board (PCB) technology is well known, reliable, and low-cost, and its application to biomedicine, which implies the integration of microfluidics and electronics, has led to Lab-on-PCB. However, the biocompatibility of the involved materials has to be examined if they are in contact with biological elements. In this paper, the solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) of a commercial PCB has been studied for retinal cultures. For this purpose, retinal explants have been cultured over this substrate, both on open and closed systems, with successful results. Cell viability data shows that the solder mask has no cytotoxic effect on the culture allowing the application of PCB as the substrate of customized microelectrode arrays (MEAs). Finally, a comparative study of the biocompatibility of the 3D printer Uniz zSG amber resin has also been carried out. |
