Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy.

Autor: Keranov S; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany., Haen S; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany., Vietheer J; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Rutsatz W; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany., Wolter JS; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Kriechbaum SD; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany.; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., von Jeinsen B; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Bauer P; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany., Tello K; Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany., Richter M; Department of Internal Medicine, Justus-Liebig-University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany., Dörr O; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany., Rieth AJ; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Nef H; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany., Hamm CW; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany.; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Liebetrau C; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany.; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany.; Cardioangiological Center Bethanien (CCB), 60389 Frankfurt, Germany., Rolf A; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany., Keller T; Department of Internal Medicine I, Cardiology and Angiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site RheinMain, 61231 Bad Nauheim, Germany.; Kerckhoff Heart and Thorax Center, Department of Cardiology, 61231 Bad Nauheim, Germany.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Nov 24; Vol. 11 (12). Date of Electronic Publication: 2021 Nov 24.
DOI: 10.3390/diagnostics11122188
Abstrakt: The main aim of this study was to assess the prognostic utility of TAPSE/PASP as an echocardiographic parameter of maladaptive RV remodeling in cardiomyopathy patients using cardiac magnetic resonance (CMR) imaging. Furthermore, we sought to compare TAPSE/PASP to TAPSE. The association of the echocardiographic parameters TAPSE/PASP and TAPSE with CMR parameters of RV and LV remodeling was evaluated in 111 patients with ischemic and non-ischemic cardiomyopathy and cut-off values for maladaptive RV remodeling were defined. In a second step, the prognostic value of TAPSE/PASP and its cut-off value were analyzed regarding mortality in a validation cohort consisting of 221 patients with ischemic and non-ischemic cardiomyopathy. A low TAPSE/PASP (<0.38 mm/mmHg) and TAPSE (<16 mm) were associated with a lower RVEF and a long-axis RV global longitudinal strain (GLS) as well as higher RVESVI, RVEDVI and NT-proBNP. A low TAPSE/PASP, but not TAPSE, was associated with a lower LVEF and long-axis LV GLS, and a higher LVESVI, LVEDVI and T1 relaxation time at the interventricular septum and the RV insertion points. Furthermore, in the validation cohort, low TAPSE/PASP was associated with a higher mortality and TAPSE/PASP was an independent predictor of mortality. TAPSE/PASP is a predictor of maladaptive RV and LV remodeling associated with poor outcomes in cardiomyopathy patients.
Databáze: MEDLINE
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