Human Microbiome in Children, at the Crossroad of Social Determinants of Health and Personalized Medicine.

Autor:	Sainz T; Hospital La Paz, Pº Castellana 261, 28046 Madrid, Spain.; La Paz Hospital Reserach Institute (IdiPAZ), Pº Castellana 261, 28046 Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERInfec), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain., Pignataro V; Consorzio per Valutazioni Biologiche e Farmacologiche, Via N. Putignani n. 178, 70122 Bari, Italy., Bonifazi D; Consorzio per Valutazioni Biologiche e Farmacologiche, Via N. Putignani n. 178, 70122 Bari, Italy.; TEDDY European Network of Excellence for Paediatric Research, Via Luigi Porta 14, 27100 Pavia, Italy., Ravera S; PHArmaceutical Research Management SRL, Via Albert Einstein, 26900 Lodi, Italy., Mellado MJ; Hospital La Paz, Pº Castellana 261, 28046 Madrid, Spain.; La Paz Hospital Reserach Institute (IdiPAZ), Pº Castellana 261, 28046 Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERInfec), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.; TEDDY European Network of Excellence for Paediatric Research, Via Luigi Porta 14, 27100 Pavia, Italy., Pérez-Martínez A; Hospital La Paz, Pº Castellana 261, 28046 Madrid, Spain.; La Paz Hospital Reserach Institute (IdiPAZ), Pº Castellana 261, 28046 Madrid, Spain.; Departamento de Pediatría, Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain., Escudero A; Hospital La Paz, Pº Castellana 261, 28046 Madrid, Spain.; La Paz Hospital Reserach Institute (IdiPAZ), Pº Castellana 261, 28046 Madrid, Spain., Ceci A; Consorzio per Valutazioni Biologiche e Farmacologiche, Via N. Putignani n. 178, 70122 Bari, Italy.; TEDDY European Network of Excellence for Paediatric Research, Via Luigi Porta 14, 27100 Pavia, Italy., Calvo C; Hospital La Paz, Pº Castellana 261, 28046 Madrid, Spain.; La Paz Hospital Reserach Institute (IdiPAZ), Pº Castellana 261, 28046 Madrid, Spain.; CIBER de Enfermedades Infecciosas (CIBERInfec), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.; Departamento de Pediatría, Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Children (Basel, Switzerland) [Children (Basel)] 2021 Dec 16; Vol. 8 (12). Date of Electronic Publication: 2021 Dec 16.
DOI:	10.3390/children8121191
Abstrakt:	The evolving field of microbiome research offers an excellent opportunity for biomarker identification, understanding drug metabolization disparities, and improving personalized medicine. However, the complexities of host-microbe ecological interactions hinder clinical transferability. Among other factors, the microbiome is deeply influenced by age and social determinants of health, including environmental factors such as diet and lifestyle conditions. In this article, the bidirectionality of social and host-microorganism interactions in health will be discussed. While the field of microbiome-related personalized medicine evolves, it is clear that social determinants of health should be mitigated. Furthermore, microbiome research exemplifies the need for specific pediatric investigation plans to improve children's health.
Databáze:	MEDLINE
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