Alterations in CNS Functions and DNA Methylation in Rats after 24 h Exposure to Peat Smoke.

Autor:	Vokina VA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Sosedova LM; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Novikov MA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Rukavishnikov VS; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Kapustina EA; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Alekseenko AN; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia., Andreeva ES; FSBSI East-Siberian Institute of Medical and Ecological Research, 665827 Angarsk, Russia.
Jazyk:	angličtina
Zdroj:	Toxics [Toxics] 2021 Dec 08; Vol. 9 (12). Date of Electronic Publication: 2021 Dec 08.
DOI:	10.3390/toxics9120342
Abstrakt:	The use of a developed experimental model of a natural fire made it possible to assess the consequences of 24 h exposure to peat combustion products in albino rats. Peat smoke exposure leads to behavioral disturbances in rats, characterized by an increase in locomotor activity and an increased level of anxiety. Indicators of brain bioelectrical activity of the exposed animals supported the state of anxiety and psychoemotional stress. Epigenetic changes in the blood cells of exposed animals were revealed under 24 h exposure to peat smoke, characterized by a decrease in the level of global DNA methylation.
Databáze:	MEDLINE
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