Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.

Autor: Spencer CN; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., McQuade JL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gopalakrishnan V; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., McCulloch JA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Vetizou M; Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Cogdill AP; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhang X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., White MG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Peterson CB; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wong MC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Morad G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Rodgers T; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Badger JH; Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Helmink BA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Andrews MC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Medicine, Monash University, Melbourne, VIC 3004, Australia., Rodrigues RR; Frederick National Laboratory for Cancer Research, and Microbiome and Genetics Core, Laboratory of Integrative Cancer Immunology, CCR, NCI, NIH, Bethesda, MD 20852, USA., Morgun A; Department of Pharmaceutical Science, Oregon State University, Corvallis, OR 97331, USA., Kim YS; Nutritional Science Research Group, Division of Cancer Prevention, NCI, NIH, Rockville, MD 20850, USA., Roszik J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hoffman KL; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Zheng J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zhou Y; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Medik YB; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kahn LM; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; MD Anderson University of Texas Health Graduate School, Houston, TX 77030, USA., Johnson S; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hudgens CW; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wani K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gaudreau PO; Canadian Cancer Trials Group and Department of Oncology, Queen's University, Kingston, ON K7L 3N6, Canada., Harris AL; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jamal MA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Baruch EN; Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA., Perez-Guijarro E; Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD 20892, USA., Day CP; Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD 20892, USA., Merlino G; Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH, Bethesda, MD 20892, USA., Pazdrak B; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lochmann BS; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Szczepaniak-Sloane RA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Arora R; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Anderson J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zobniw CM; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Posada E; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sirmans E; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Simon J; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Burton EM; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Dang M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Clise-Dwyer K; Advanced Cytometry and Sorting Facility at South Campus, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Schneider S; Advanced Cytometry and Sorting Facility at South Campus, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chapman T; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Anang NAS; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Duncan S; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Toker J; Department of Neurosurgery, Harvard University, Cambridge, MA 02138, USA.; Department of Oncology, University of Cambridge, Cambridge CB2 1TN, UK., Malke JC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Glitza IC; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Amaria RN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tawbi HA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Diab A; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wong MK; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Patel SP; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Woodman SE; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ross MI; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lee JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Jensen V; Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Samuels Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel., Straussman R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel., Ajami NJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Nelson KC; Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Nezi L; Dipartimento di Oncologia Sperimentale, Instituto Europeo di Oncologia, Milan, P.I. 08691440153, Italy., Petrosino JF; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Lazar AJ; MD Anderson University of Texas Health Graduate School, Houston, TX 77030, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hu J; Department of Biostatistics, Columbia University, New York, NY 10032, USA., Jenq RR; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Stem Cell Transplant, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tetzlaff MT; Departments of Pathology and Dermatology, Dermatopathology and Oral Pathology Unit, University of California San Francisco, San Francisco, CA 94115, USA., Yan Y; Department of Biostatistics and the Harvard T.H. Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Garrett WS; Department of Molecular Metabolism, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA., Huttenhower C; Department of Biostatistics and the Harvard T.H. Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Sharma P; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Watowich SS; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Allison JP; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Cohen L; Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Trinchieri G; Laboratory of Integrative Cancer Immunology, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892, USA., Daniel CR; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2021 Dec 24; Vol. 374 (6575), pp. 1632-1640. Date of Electronic Publication: 2021 Dec 23.
DOI: 10.1126/science.aaz7015
Abstrakt: Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probiotic supplement use in melanoma patients and performed parallel preclinical studies. Higher dietary fiber was associated with significantly improved progression-free survival in 128 patients on ICB, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use. Findings were recapitulated in preclinical models, which demonstrated impaired treatment response to anti–programmed cell death 1 (anti–PD-1)–based therapy in mice receiving a low-fiber diet or probiotics, with a lower frequency of interferon-γ–positive cytotoxic T cells in the tumor microenvironment. Together, these data have clinical implications for patients receiving ICB for cancer.
Databáze: MEDLINE
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