| Autor: |
Eriksen EF; Spesialistsenteret Pilestredet Park and Department of Odontology, University of Oslo, 0315 Oslo, Norway., Lech O; Shoulder and Elbow Service, Hospital Sao Vicente de Paulo, and Instituto de Ortopedia e Traumatologia, R. Uruguai, 2050-Centro, Passo Fundo 99010-112, Brazil., Nakama GY; Articulare Clínica Integrada, Alameda dos Maracatins, 1217-Cj. 517-Indianópolis, São Paulo 04089-014, Brazil., O'Gorman DM; Marigot Ltd., Carrigaline Co., P43 E409 Cork, Ireland. |
| Jazyk: |
angličtina |
| Zdroj: |
Clinics and practice [Clin Pract] 2021 Nov 26; Vol. 11 (4), pp. 901-913. Date of Electronic Publication: 2021 Nov 26. |
| DOI: |
10.3390/clinpract11040104 |
| Abstrakt: |
Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the 'inflammatory theory' of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal ® Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal ® has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal ® Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal ® Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal ® Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal ® Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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