What is beyond LncRNAs in breast cancer: A special focus on colon cancer-associated Transcript-1 (CCAT-1).
| Autor: | Selem NA; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt., Youness RA; Molecular Genetics Research Team (MGRT), Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, 11586, Cairo, Egypt., Gad MZ; Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Non-coding RNA research [Noncoding RNA Res] 2021 Dec 01; Vol. 6 (4), pp. 174-186. Date of Electronic Publication: 2021 Dec 01 (Print Publication: 2021). |
| DOI: | 10.1016/j.ncrna.2021.11.001 |
| Abstrakt: | Long non-coding RNAs (LncRNAs) play a vital role in the process of malignant transformation. In breast cancer (BC), lncRNAs field is currently under intensive investigations. Yet, the role of lncRNAs as promising diagnostic and/or prognostic biomarkers and as therapeutic target/tool among BC patients still needs a special focus from the biomedical scientists. In BC, triple negative breast cancer patients (TNBC) are the unlucky group as they are always represented with the worst prognosis and the highest mortality rates. For that reason, a special focus on TNBC and associated lncRNAs was addressed in this review. Colon cancer-associated transcript 1 (CCAT-1) is a newly discovered oncogenic lncRNA that has been emerged as a vital biomarker for diagnosis, prognosis and therapeutic interventions in multiple malignancies and showed differential expression among TNBC patients. In this review, the authors shed the light onto the general role of lncRNAs in BC and the specific functional activities, molecular mechanisms, competing endogenous ncRNA role of CCAT-1 in TNBC. Competing Interests: The authors declare no conflict of interest. (© 2021 The Authors.) |
| Databáze: | MEDLINE |
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