The evaluation of serum brain-derived neurotrophic factor and neurofilament light chain levels in patients with obstructive sleep apnea syndrome.

Autor: Arslan B; Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey.; Department of Medical Biochemistry Erciş State Hospital Van Turkey., Şemsi R; Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey., İriz A; Department of Otorhinolaryngology (Ear-Nose-Throat) Gazi University Faculty of Medicine Ankara Turkey., Sepici Dinçel A; Department of Medical Biochemistry Gazi University Faculty of Medicine Ankara Turkey.
Jazyk: angličtina
Zdroj: Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2021 Oct 20; Vol. 6 (6), pp. 1466-1473. Date of Electronic Publication: 2021 Oct 20 (Print Publication: 2021).
DOI: 10.1002/lio2.683
Abstrakt: Objectives: This study aimed to compare serum levels of brain-derived neurotrophic factor (BDNF) and neurofilament light (NfL) chain in normal individuals and patients with mild and moderate-severe obstructive sleep apnea syndrome (OSAS).
Methods: We enrolled 81 subjects referred to Otorhinolaryngology (Ear-Nose-Throat), Gazi University Faculty of Medicine, between 2017 and 2019. Based on the severity of OSAS, patients were divided into three groups: group 1 with mild OSAS (apnea-hypopnea index [AHI] 5-15; n = 26), group 2 with moderate-severe OSAS (AHI > 15; n = 32), and group 3 with normal individuals (AHI scores < 5; n = 23).
Results: Serum NfL and BDNF levels were evaluated together with the clinical data for all subjects. Significant differences were seen in the oxygen desaturation index (ODI), apnea index, hypopnea index, sleep efficiency, and NfL levels ( P  < .05) between the three groups. In the moderate-severe group, NfL levels showed a significant positive correlation with apnea index ( P  < .05, r  = .389), hypopnea index ( P  < .05, r  = .455), and ODI ( P  = .04; r  = .362).
Conclusions: Our findings clarify the pathophysiology of OSAS in cases of repetitive hypoxia and chronic neuronal damage. Based on our results, we recommend that in addition to BDNF, NfL should also be evaluated in different and larger patient cohorts.
Competing Interests: The authors have no conflicts of interest to declare.
(© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.)
Databáze: MEDLINE
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