| Autor: |
Mudde AH, van den Berg H, Boshuis PG, Breedveld FC, Markusse HM, Kluin PM, Bijvoet OL, Papapoulos SE |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer [Cancer] 1987 May 01; Vol. 59 (9), pp. 1543-6. |
| DOI: |
10.1002/1097-0142(19870501)59:9<1543::aid-cncr2820590902>3.0.co;2-l |
| Abstrakt: |
A patient with long-standing rheumatoid arthritis developed hypercalcemia (3.13 mmol/l) and was subsequently found to have a B-cell lymphoma (centroblastic type). The hypercalcemia was associated with high circulating concentrations of 1,25-dihydroxyvitamin D (235 pmol/l) and both abnormalities were corrected with treatment. A lymph node was excised before treatment and was incubated in vitro with either labeled or unlabeled 25-hydroxyvitamin D3. After purification of the extract and chromatography on three different HPLC systems, material comigrating with authentic 1,25-dihydroxyvitamin D3 was identified. This was shown to bind to a specific chick intestinal cytosol receptor and to dilute in parallel with synthetic 1,25-dihydroxyvitamin D3 in the receptor binding assay. In conclusion, hypercalcemia in malignant B-cell lymphoma can be due to extrarenal production of 1,25-dihydroxyvitamin D by lymphomatous tissue. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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