| Autor: |
Ninh Thi N; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Tran Thi Hong H; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Tran Hong Q; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nguyen Xuan C; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Nguyen Hoai N; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Thi Thao D; Institute of Biotechnology (IBT), VAST, Hanoi, Vietnam., Cuong PV; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Do Cong T; Institute of Marine Environment and Resources (IMER), VAST, Haiphong, Vietnam., Phan Van K; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam., Van Minh C; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam. |
| Abstrakt: |
Using various chromatographic separations, two new cembranoids, ehrenbergols F and G ( 1 and 2 ), along with three known analogs ehrenbergol D ( 3 ), (+)-isosarcophine ( 4 ) and sinulariol Z 2 ( 5 ) were isolated from the soft coral Sarcophyton ehrenbergi . The structural elucidation was done by extensive analysis of the 1 D and 2 D NMR, HR-ESI-QTOF-MS as well as CD experiments. In addition, compounds 1 (IC 50 of 38.38 ± 2.89 µM), 3 (IC 50 of 37.14 ± 3.22 µM) and 4 (IC 50 of 45.01 ± 2.49 µM) revealed moderate inhibitory activity on LPS-induced NO production in RAW264.7 cells, whereas 2 (IC 50 of 73.32 ± 1.95 µM) and 5 (IC 50 of 64.48 ± 4.93 µM) exhibited weak effect. |
