| Autor: |
Wong GG, Temple PA, Leary AC, Witek-Giannotti JS, Yang YC, Ciarletta AB, Chung M, Murtha P, Kriz R, Kaufman RJ, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1987 Mar 20; Vol. 235 (4795), pp. 1504-8. |
| DOI: |
10.1126/science.3493529 |
| Abstrakt: |
A 4-kilobase complementary DNA (cDNA) encoding human macrophage-specific colony-stimulating factor (CSF-1) was isolated. When introduced into mammalian cells, this cDNA directs the expression of CSF-1 that is structurally and functionally indistinguishable from the natural human urinary CSF-1. Direct structural analysis of both the recombinant CSF-1 and the purified human urinary protein revealed that these species contain a sequence of at least 40 amino acids at their carboxyl termini which are not found in the coding region of a 1.6-kilobase CSF-1 cDNA that was previously described. These results demonstrate that the human CSF-1 gene can be expressed to yield at least two different messenger RNA species that encode distinct but related forms of CSF-1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
