δ -Tocopherol derivatives from the leaves of Muntingia calabura L.

Autor:	Van Do TN; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Le TH; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Nguyen HX; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Vo TNT; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Dang PH; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam., Nguyen NT; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam.; Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam., Nguyen MTT; Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam.; Cancer Research Laboratory, University of Science, Ho Chi Minh City, Vietnam.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2022 Nov; Vol. 36 (21), pp. 5524-5529. Date of Electronic Publication: 2021 Dec 21.
DOI:	10.1080/14786419.2021.2018589
Abstrakt:	From an ethyl acetate-soluble fraction of the leaves of Muntingia calabura , one new trimeric δ -tocopherol derivative named as tocomuntin A ( 1 ), together with three known δ -tocopherol derivatives ( 2 - 4 ) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, δ -tocopherol ( 3 ) was found to have α -glucosidase inhibitory activity for the first time (IC 50 , 47.3  μ M).
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu