Assessing Photosensitized Membrane Damage: Available Tools and Comprehensive Mechanisms.

Autor: Rezende LG; Chemistry Department, Institute of Exact Sciences, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil., Tasso TT; Chemistry Department, Institute of Exact Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Candido PHS; Biochemistry Department, Chemistry Institute, Universidade de São Paulo, Sao Paulo, Brazil., Baptista MS; Biochemistry Department, Chemistry Institute, Universidade de São Paulo, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Photochemistry and photobiology [Photochem Photobiol] 2022 May; Vol. 98 (3), pp. 572-590. Date of Electronic Publication: 2021 Dec 28.
DOI: 10.1111/php.13582
Abstrakt: Lipids are important targets of the photosensitized oxidation reactions, forming important signaling molecules, disorganizing and permeabilizing membranes, and consequently inducing a variety of biological responses. Although the initial steps of the photosensitized oxidative damage in lipids are known to occur by both Type I and Type II mechanisms, the progression of the peroxidation reaction, which leads to important end-point biological responses, is poorly known. There are many experimental tools used to study the products of lipid oxidation, but neither the methods nor their resulting observations were critically compared. In this article, we will review the tools most frequently used and the key concepts raised by them in order to rationalize a comprehensive model for the initiation and the progression steps of the photoinduced lipid oxidation.
(© 2021 American Society for Photobiology.)
Databáze: MEDLINE
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