Impact of zinc oxide, benzoic acid and probiotics on the performance and cecal microbiota of piglets.

Autor: da Silva CA; Department of Animal Science, Universidade Estadual de Londrina, Londrina, Paraná, Brazil. casilva@uel.br., Bentin LAT; Department of Clinics, Surgery and Animal Reproduction, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil.; Department of Veterinary Biomedical Sciences, Université de Montréal, Saint-Hyacinthe, Québec, Canada., Dias CP; Akei Animal Research, Fartura, São Paulo, Brazil., Callegari MA; Akei Animal Research, Fartura, São Paulo, Brazil., Facina VB; DSM Nutritional Products Ltd., Jaguaré, São Paulo, Brazil., Dias FTF; DSM Nutritional Products Ltd., Jaguaré, São Paulo, Brazil., Passos A; DSM Nutritional Products Ltd., Jaguaré, São Paulo, Brazil., da Silva Martins CC; DSM Nutritional Products Ltd., Jaguaré, São Paulo, Brazil., Costa MC; Department of Veterinary Biomedical Sciences, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
Jazyk: angličtina
Zdroj: Animal microbiome [Anim Microbiome] 2021 Dec 20; Vol. 3 (1), pp. 86. Date of Electronic Publication: 2021 Dec 20.
DOI: 10.1186/s42523-021-00151-y
Abstrakt: Background: Intestinal health remains a key factor in animal production because it is essential for digestion, absorption and bacterial fermentation. Feed additives have been used to attenuate the weaning stress such as Zinc Oxide (ZnO) and benzoic acid (C 7 H 6 O 2 ). The objective of this study was to evaluate the impact of of benzoic acid and probiotics (BA + P) on performance, diarrhea and cecal microbiota of piglets in the nursery phase (23 to 65 days).
Results: One hundred and sixty weaned piglets with an initial weight of 6.335 ± 0.698 kg and 23 days of age were submitted to four treatments: supplementation with 2500 ppm of Zinc oxide (ZnO), supplementation with a commercial blend of benzoic acid and probiotics (Bacillus licheniformis, Bacillus subtilis and Enterococcus faecium NCIMB 10415; Vevogut P®) (BA + P), supplementation with Zinc oxide plus benzoic acid and probiotics (ZnO + BA + P), and controls receiving only the basal diet without any supplementation. At 65 days of age, 32 piglets (n = 8 per treatment) were slaughtered for the evaluation of the cecal microbiota. Supplementation with ZnO and BA + P were associated with better feed conversion (P < 0.05) in the early stage (23 to 49 days) and with an improvement in all performance parameters over the entire experimental period. The occurrence of diarrhea was lower (P < 0.05) in the BA + P group. The 4 most abundant phyla along with unclassified bacteria represented 93% of all sequences. Firmicutes dominated the cecal microbiota of all groups, followed by Bacteroidetes. Richness represented by the observed number of genera and by the Chao index were statistically lower in ZnO and ZnO + BA + P supplemented animals compared to controls. The beta diversity analysis that compares similarities between bacterial communities demonstrated formation of two distinct clusters containing samples with and without supplementation with ZnO, confirming a strong influence of ZnO on the intestinal microbiota.
Conclusion: The use of Benzoic acid with probiotics yields similar performance results with lower impact on the gut microbiota compared to ZnO, and it should be considered as a potential alternative in swine production.
(© 2021. The Author(s).)
Databáze: MEDLINE