Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio.

Autor: Kökönyei G; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary., Galambos A; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.; Doctoral School of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary., Kocsel N; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary., Szabó E; Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary.; Center for Pain and the Brain (PAIN Research Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States of America., Édes AE; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary., Gecse K; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary., Baksa D; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary., Pap D; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary., Kozák LR; MR Research Center, Semmelweis University, Budapest, Hungary., Bagdy G; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary., Juhász G; SE-NAP2 Genetic Brain Imaging Migraine Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.; Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Dec 20; Vol. 16 (12), pp. e0261570. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0261570
Abstrakt: Previous studies targeting inter-individual differences in pain processing in migraine mainly focused on the perception of pain. Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases. Functional Magnetic Resonance Imaging (fMRI) data of 23 participants (18 females; mean age: 27.61± 5.36) with episodic migraine without aura were analysed. We found that migraine frequency was significantly associated with pain anticipation in brain regions comprising the midcingulate and caudate, whereas pre-scan cortisol-to DHEA-S ratio was related to pain perception in the pre-supplementary motor area (pre-SMA). Both results suggest exaggerated preparatory responses to pain or more general to stressors, which may contribute to the allostatic load caused by stressors and migraine attacks on the brain.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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