Matching chemical properties to molecular biological activities opens a new perspective on l-ergothioneine.
| Autor: | Yadan JC; Tetrahedron, Paris, France. |
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| Jazyk: | angličtina |
| Zdroj: | FEBS letters [FEBS Lett] 2022 May; Vol. 596 (10), pp. 1299-1312. Date of Electronic Publication: 2022 Jan 19. |
| DOI: | 10.1002/1873-3468.14264 |
| Abstrakt: | l-ergothioneine is a low-molecular weight natural product, the chemical structure of which comprises oxygen-, nitrogen- and sulfur-containing functional groups. This gives l-ergothioneine specific physicochemical properties and allows a better understanding of its chemical reactivity, which is primarily due to the 2-thio-imidazole group. Here, a review is provided of how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine. By matching the physicochemical properties to the biological properties of l-ergothioneine, a new perspective of the function and the mode of action of this enigmatic molecule emerges. (© 2022 Federation of European Biochemical Societies.) |
| Databáze: | MEDLINE |
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