Higher Incidence of Metabolic Syndrome in Black Women With Polycystic Ovary Syndrome: A Longitudinal Study.

Autor:	Lee I; Department of Obstetrics and Gynecology, University of Pennsylvania; Philadelphia, PA 19104, USA., Vresilovic J; Department of Obstetrics and Gynecology, University of Pennsylvania; Philadelphia, PA 19104, USA., Irfan M; Department of Obstetrics and Gynecology, University of Pennsylvania; Philadelphia, PA 19104, USA., Gallop R; Department of Biostatistics, University of Pennsylvania; Philadelphia, PA 19104, USA., Dokras A; Department of Obstetrics and Gynecology, University of Pennsylvania; Philadelphia, PA 19104, USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Mar 24; Vol. 107 (4), pp. e1558-e1567.
DOI:	10.1210/clinem/dgab840
Abstrakt:	Context: Cross-sectional studies have identified an increased risk of metabolic syndrome (MetSyn) in women with polycystic ovary syndrome (PCOS), but longitudinal data are limited and primarily include White and European cohorts. Objective: To compare the longitudinal risk of MetSyn in Black and White women with PCOS and to identify potential factors mediating the risk of MetSyn. Methods: Longitudinal cohort study with a follow-up of 5.3 years at an academic medical center. Of: 247 adult women with hyperandrogenic PCOS phenotype with 2 or more visits at least 3 years apart. The main outcome measure was incidence of MetSyn in Black and White women with PCOS. Results: Using a mixed-effects model over time, the incidence of MetSyn was higher in Black women (45.9 ± 4.74 per 100 person-years) than in White women (31.3 ± 3.03 per 100 person-years) (P < .01) after adjusting for age and medication status. This difference persisted among women under age 30. Among Black women who did not have MetSyn at their prior visit, 28.0% had MetSyn at the next visit, compared with 12.1% of White women after adjusting for age and medication status (P < .01). In both races, the model-based estimated rates of MetSyn increased significantly with increase in body mass index and free testosterone. Conclusion: We describe a persistent higher incidence of MetSyn in Black than in White women with PCOS. In addition to early cardiometabolic screening at the time of diagnosis, our findings highlight the need for ongoing and frequent screening in this population. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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