Investigation of Antibacterial Activity and Cell Viability of Ag/Mg and Ag/Zn Co-doped Hydroxyapatite Derived from Natural Limestone.

Autor:	Sinulingga K; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan 20221, Indonesia., Sirait M; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan 20221, Indonesia., Siregar N; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan 20221, Indonesia., Doloksaribu ME; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan 20221, Indonesia.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2021 Nov 30; Vol. 6 (49), pp. 34185-34191. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).
DOI:	10.1021/acsomega.1c05921
Abstrakt:	Improving the antibacterial activity to avoid infections and keeping the biocompatibility at a safe level of HAp-based materials is highly important for biomedical applications. In this work, we investigate the antibacterial activity of 2.5Ag/2.5Mg co-doped HAp and 2.5Ag/2.5Zn co-doped HAp toward Escherichia coli bacteria. Moreover, their biocompatibility for osteoblastic cells (MC3T3-E1 cells) was also evaluated. The physical properties were characterized with necessary characterization tools such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Brunauer-Emmett-Teller. Both 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp consist of hydroxyapatite (HAp) and beta calcium triphosphate (β-TCP) phases. The antibacterial test reveals that 2.5Ag/2.5Mg co-doped HAp or 2.5Ag/2.5Zn co-doped HAp has an outstanding antibacterial activity with a killing rate of 99 ± 1%. More importantly, the cell viability for osteoblast cells with 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp promotes the proliferation much more effectively than 2.5Ag-doped HAp or 5Ag-doped HAp. Competing Interests: The authors declare no competing financial interest. (© 2021 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu