Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium.

Autor: Case DR; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States., Gonzalez R; Balchem Corporation, 52 Sunrise Park Road, New Hampton, New York 10958, United States., Zubieta J; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States., Doyle RP; 111 College Place, Department of Chemistry, Syracuse University, Syracuse, New York 13244, United States.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2021 Nov 30; Vol. 6 (49), pp. 33454-33461. Date of Electronic Publication: 2021 Nov 30 (Print Publication: 2021).
DOI: 10.1021/acsomega.1c04146
Abstrakt: Human chronic latent magnesium deficiency is estimated to impact a substantive portion of the world's population. A number of magnesium compounds have been developed to combat this deficiency; however, none are ideal due to issues of solubility, absorption, side effects (e.g., laxation) and/or formulation. Here, we describe the pH-dependent synthesis, chemical characterization (inductively coupled plasma and thermal analysis, infrared and nuclear magnetic resonance (1D and 2D) spectroscopies, and electrospray mass spectrometry) and in vitro uptake (in a cell model of the large intestine (CaCo-2 cells)) of a magnesium complex of the glycine dimer (HG 2 ). Results demonstrate that the HG 2 ligand assumes a tridentate coordination mode with an N 2 O donor set and an octahedral coordination sphere completed with coordinated waters. The magnesium:HG 2 complex exhibits significant solubility and cellular uptake.
Competing Interests: The authors declare the following competing financial interest(s): RPD is a paid scientific advisory board member of Balchem Corporation.
(© 2021 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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