Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis.

Autor:	Melhuish Beaupre LM; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Tiwari AK; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Gonçalves VF; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Zai CC; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Marshe VS; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Lewis CM; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.; Department of Medical and Molecular Genetics, King's College London, London, United Kingdom., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom., Adams MJ; Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom., Baune BT; Department of Psychiatry, University of Münster, Münster, Germany.; Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.; Melbourne Medical School, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia., Levinson DF; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States., Boomsma DI; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Breen G; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom.; National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre, King's College London, London, United Kingdom., Hamilton S; The Permanente Medical Group, San Francisco, CA, United States., Awasthi S; Department of Psychiatry and Psychotherapy, Universitäts Medizin Berlin Campus Charité Mitte, Berlin, Germany., Ripke S; Department of Psychiatry and Psychotherapy, Universitäts Medizin Berlin Campus Charité Mitte, Berlin, Germany.; Analytic and Translational Genetic Unit, Massachusetts General Hospital, Boston, MA, United States.; Medical and Population Genetics, Broad Institute, Cambridge, MA, United States.; Department of Psychiatry, Charité, Berlin, Germany., Jones L; Psychological Medicine, University of Worcester, Worcester, United Kingdom., Jones I; Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom., Byrne EM; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Hickie IB; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., Potash JP; Psychiatry Department, University of Iowa, Iowa City, IA, United States., Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States., Weissman MM; Psychiatry Department, Columbia University College of Physicians and Surgeons, New York, NY, United States.; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, United States., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Shyn SI; Washington Permanente Medical Group, Kaiser Permanente Washington Health Research Institute, Seattle, WA, United States., de Geus EJC; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Willemsen G; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC/Vrije Universiteit, Amsterdam, Netherlands., Brown GM; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada., Kennedy JL; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2021 Dec 03; Vol. 12, pp. 734077. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).
DOI:	10.3389/fpsyt.2021.734077
Abstrakt:	Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many promising hits for genetics of insomnia in a population-based sample. Methods: Using data from the largest available GWAS of insomnia and other sleep traits, we sought to test if sleep variable PRS scores derived from population-based studies predicted sleep variables in samples of depressed cases [Psychiatric Genomics Consortium - Major Depressive Disorder subjects (PGC MDD)]. A leave-one-out analysis was performed to determine the effects that each individual study had on our results. Results: The only significant finding was for insomnia, where p -value threshold, p = 0.05 was associated with insomnia in our PGC MDD sample ( R 2 = 1.75 -3 , p = 0.006). Conclusion: Our results reveal that <1% of variance is explained by the variants that cover the two significant p -value thresholds, which is in line with the fact that depression and insomnia are both polygenic disorders. To the best of our knowledge, this is the first study to investigate genetic overlap between the general population and a depression sample for insomnia, which has important treatment implications, such as leading to novel drug targets in future research efforts. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Melhuish Beaupre, Tiwari, Gonçalves, Zai, Marshe, Lewis, Martin, McIntosh, Adams, Baune, Levinson, Boomsma, Penninx, Breen, Hamilton, Awasthi, Ripke, Jones, Jones, Byrne, Hickie, Potash, Shi, Weissman, Milaneschi, Shyn, Geus, Willemsen, Brown, Kennedy and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.)
Databáze:	MEDLINE
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