Level of physical activity and gene expression of IL-10 and TNF-α in children and adolescents with Type 1 diabetes.

Autor: Dos Santos Haber JF; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil; Interdisciplinary Center on Diabetes (CENID) - UNIMAR, Marília, SP, Brazil., Chagas EFB; Interdisciplinary Center on Diabetes (CENID) - UNIMAR, Marília, SP, Brazil; Postgraduate Program in Structural and Functional Interactions in Rehabilitation - UNIMAR, Marília, SP, Brazil; Postgraduate of Health and Aging Program, Faculdade de Medicina de Marilia, Marília, São Paulo, Brazil., Barbalho SM; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil; Interdisciplinary Center on Diabetes (CENID) - UNIMAR, Marília, SP, Brazil; Postgraduate Program in Structural and Functional Interactions in Rehabilitation - UNIMAR, Marília, SP, Brazil. Electronic address: smbarbalho@gmail.com., Sgarbi JA; Postgraduate of Health and Aging Program, Faculdade de Medicina de Marilia, Marília, São Paulo, Brazil., Haber RSA; Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Avenida Higino Muzzi Filho, 1001, Marília, São Paulo, Brazil., de Labio RW; Postgraduate of Health and Aging Program, Faculdade de Medicina de Marilia, Marília, São Paulo, Brazil., Payão SLM; Postgraduate of Health and Aging Program, Faculdade de Medicina de Marilia, Marília, São Paulo, Brazil; Department of Genetics - Faculdade de Medicina de Marília, Marília, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2022 Feb; Vol. 36 (2), pp. 108104. Date of Electronic Publication: 2021 Dec 16.
DOI: 10.1016/j.jdiacomp.2021.108104
Abstrakt: Aims: The gene expressions of IL-10 and TNF-α have been identified as important factors of the clinical condition in type I diabetes mellitus (DM1). However, the effect of physical exercise on the expression of these markers is poorly understood. Our objective was to evaluate the relationship between the level of physical activity (LPA) and the gene expressions of IL-10 and TNF-α, as the relationship with glycemic control and insulin reserve in children and adolescents with DM1.
Methods: 108 participants (1-23 years), were divided into 4 groups: DM1 with ketoacidosis (KETO) (n = 15); Decompensated DM1 (DM1d) (n = 32); Compensated DM1 (DM1c) (n = 30); and healthy control (C) (n = 30). The level of physical activity (LPA) was classified as low active, active, and very active. So evaluated Fasting blood glucose, HbA1c, C-peptide, and gene expressions of IL-10 and TNF-α.
Results: The increase in the level of physical activity significantly affected the expression of TNF-α in the DMd and C groups. The increase in LPA from low to active reduced the gene expression of IL-10; however, the increase in NAF from active to very active was associated with an increase in IL-10 gene expression. A very active LPA contributes to reducing HbA1c and an increase in C-peptide in the KETO group.
Conclusion: The increase in LPA demonstrated a significant effect on the improvement of IL-10 and TNF-α gene expression in the KETO and DMd groups; however, in the KETO group, improvements were also observed in the percentage of HbA1C and C-peptide.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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