From Alpha Diversity to Zzz: Interactions among sleep, the brain, and gut microbiota in the first year of life.

Autor: Schoch SF; Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland., Castro-Mejía JL; Department of Food Science, University of Copenhagen, Copenhagen, Denmark., Krych L; Department of Food Science, University of Copenhagen, Copenhagen, Denmark., Leng B; Department of Food Science, University of Copenhagen, Copenhagen, Denmark., Kot W; Department of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, Denmark., Kohler M; Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland., Huber R; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland; Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland., Rogler G; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland., Biedermann L; Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland., Walser JC; Genetic Diversity Center, ETH Zurich, Zurich, Switzerland., Nielsen DS; Department of Food Science, University of Copenhagen, Copenhagen, Denmark., Kurth S; Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland; Center of Competence Sleep & Health Zurich, University of Zurich, Zurich, Switzerland; Department of Psychology, University of Fribourg, Fribourg, Switzerland. Electronic address: salome.kurth@unifr.ch.
Jazyk: angličtina
Zdroj: Progress in neurobiology [Prog Neurobiol] 2022 Feb; Vol. 209, pp. 102208. Date of Electronic Publication: 2021 Dec 16.
DOI: 10.1016/j.pneurobio.2021.102208
Abstrakt: Sleep disorders have been linked to alterations of gut microbiota composition in adult humans and animal models, but it is unclear how this link develops. With longitudinal assessments in 162 healthy infants, we present a so far unrecognized sleep-brain-gut interrelationship. First, we report a link between sleep habits and gut microbiota: daytime sleep is associated with bacterial diversity, and nighttime sleep fragmentation and variability are linked with bacterial maturity and enterotype. Second, we demonstrate a sleep-brain-gut link: bacterial diversity and enterotype are associated with sleep neurophysiology. Third, we show that the sleep-brain-gut link is relevant in development: sleep habits and bacterial markers predict behavioral-developmental outcomes. Our results demonstrate the dynamic interplay between sleep, gut microbiota, and the maturation of brain and behavior during infancy, which aligns with the newly emerging concept of a sleep-brain-gut axis. Importantly, sleep and gut microbiota represent promising health targets since both can be modified non-invasively. As many adult diseases root in early childhood, leveraging protective factors of adequate sleep and age-appropriate gut microbiota in infancy could constitute a health promoting factor across the entire human lifespan.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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