Novel benzoylthiourea derivatives had differential anti-inflammatory photodynamic therapy potentials on in vitro stimulated mammalian macrophages.

Autor: Emen FM; Department of Chemistry, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur 15100, Turkey. Electronic address: femen@mehmetakif.edu.tr., Kutlu E; Department of Chemistry, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur 15100, Turkey., Karacolak AI; Department of Chemistry, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur 15100, Turkey., Ali MA; Department of Chemistry, Faculty of Arts and Sciences, Burdur Mehmet Akif Ersoy University, Burdur 15100, Turkey., Demirdogen RE; Department of Chemistry, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey., Yesilkaynak T; Department of Chemistry Technology, Afsin Vocational School, Kahramanmaraş Sütcü İmam University, Kahramanmaras TR46500, Turkey., Erat S; Vocational School of Technical Sciences, Department of Medical Services and Techniques, Program of Opticianry, Mersin University, Mersin 33340, Turkey; Advanced Technology Education, Research and Application Center, Mersin University, Mersin 33340, Turkey., Ayaz F; Department of Biotechnology, Faculty of Arts and Science, Mersin University, Mersin 33110, Turkey; Biotechnology Research Center, Mersin University, 33040, Turkey. Electronic address: adress.furkanayaz@mersin.edu.tr.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Mar; Vol. 37, pp. 102685. Date of Electronic Publication: 2021 Dec 15.
DOI: 10.1016/j.pdpdt.2021.102685
Abstrakt: Novel benzoylthioureas, N-((5-chloropyridin-2yl)carbamothioyl)benzamide, (HL 1 ), N-((2-chloropyridin-3yl)carbamothioyl)benzamide, (HL 2 ), N-((5-bromopyridin-2yl)carbamothioyl)benzamide, (HL 3 ) and N-(Naphthalene-1-yl(phenyl)carbamothioyl)benzamide, (HL 4 ), were synthesized. Their characterizations were made by FT-IR, 1 H NMR and 13 C NMR spectrophotometric analysis. Single crystal X-ray diffraction measurements were conducted to determine the crystal structure of HL 1 and HL 4 .  The HL 1 crystallization conditions are: in the monoclinic crystal system with P2 1 /c space group, Z = 2, a = 8.118(2) Å, b = 12.056(3) Å, c = 13.753(4) Å. HL 4 crystallization conditions are: in the orthorhombic crystal system with Pbca space group, Z = 8, a = 19.597(9) Å, b = 8.270(4) Å, c = 24.299(11) Å. Investigation of photodynamic and antiinflamatory effects of these compounds revealed that they are potent adducts. Using these derivatives, mammalian macrophages were stimulated with LPS to test their anti-inflammatory activity. Based on pro-inflammatory cytokine production levels, the photodynamic anti-inflammatory activity of these adducts were found to differ. Our results showedthat benzoylthioureas can be used as potential photodynamic therapy agents to suppress the excessive inflammatory reactions encountered in autoimmune and inflammatory disorders.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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